StemCells Inc.

StemCells Inc. is engaged in the research and development of cell-based therapeutics. The company's proprietary HuCNS-SC cells (purified human neural stem cells) are currently in development as a potential treatment for a broad range of central nervous system disorders. The company is currently conducting phase 1/2 clinical trials in chronic spinal cord injury and dry age-related macular degeneration. StemCells Inc. is also pursuing preclinical studies in Alzheimer's disease, with support from the California Institute for Regenerative Medicine. The company markets stem cell research products, including media and reagents, under the SC Proven brand.

Expert Comments:

Katherine Genis, Edison Investment Research (1/7/15)
"StemCells Inc.'s human neural stem cells (HuCNS-SC) are currently in clinical trials for dry age-related macular degeneration (AMD) and spinal cord injuries; a Phase 2 study program in both indications is underway, following early signs of efficacy in Phase 1/2 trials. Dry AMD could be a sizeable opportunity (we estimate $2B in peak sales) and represents the bulk of our overall valuation of the company at $189M, or $2.75/share."

Jason Kolbert, Maxim Group (12/22/14)
"StemCells Inc. announced that the first patient in the Phase 2 Pathway study in cervical spinal cord injury (SCI) was transplanted with its proprietary HuCNS-SCs (purified human neural stem cells). . .the primary endpoints will assess changes in patient upper extremity strength as measured in the hands, arms and shoulders. . .in May of 2014, enrollment and dosing of 12 SCI patients as part of a phase I/II study was completed. . .combined with a favorable safety profile this early data is suggestive that HuCNS-SCs have efficacy in SCI. . .our metrics may prove conservative as the company approaches mature proof-of-concept data."

"StemCells Inc. held its first analyst day event on Nov. 20. One of the biggest questions was whether the company would be able to produce its cell-based therapeutic, HuCNS-SC (purified adult human neuronal cells of fetal origin), to scale. HuCNS-SC is a central nervous system-based therapeutic that differentiates into multiple cell lines—neural cells, glial cells and astrocytes. The company does have the ability, at least based on our conversations, to produce billions of cells at both Phase 3 clinical and commercial levels. . .

I definitely think there is extraordinary upside potential on this name, and there are meaningful milestones to get this stock to my target price of $6/share within the next 24 months." read more >

Stephen Dunn, LifeTech Capital (11/17/14)
"StemCells Inc. initiated a controlled Phase 2 trial ('the Pathway Study') of its HuCNS-SC in cervical spinal cord injury patients. . .the patients will be randomized to either a HuCNS-SC treatment arm or a nontreatment arm with blinded outcome assessment in approximately 12 centers in North America. It is expected to complete enrollment within one year."

Stephen Dunn, LifeTech Capital (10/7/14)
"StemCells Inc. announced it initiated the Phase 2 proof-of-concept clinical trial (the Pathway study) using its proprietary HuCNS-SC platform of human neural stem cells for the treatment of cervical spinal cord injury (SCI). The Pathway study is the first clinical study designed to evaluate both the safety and efficacy of transplanting stem cells into patients with traumatic injury to the cervical spinal cord."

Jason Kolbert, Maxim Group (10/7/14)
"StemCells Inc. announced the launch of the Pathway study, a Phase 2 proof-of-concept clinical trial using its HuCNS-SC platform of human neural stem cells for the treatment of cervical spinal cord injury. . .the first site initiated into the Pathway study is the University of Miami Miller School of Medicine."

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