Sunesis Pharmaceuticals Inc.

Sunesis Pharmaceuticals Inc. is a biopharmaceutical company focused on the development and commercialization of new oncology therapeutics for the treatment of solid and hematologic cancers. The company has built a highly experienced cancer drug development organization committed to advancing its lead product candidate, vosaroxin, in multiple indications to improve the lives of people with cancer.

Expert Comments:

Hartaj Singh, BTIG Research (5/10/16)
"Sunesis Pharmaceuticals Inc. provided a deeper dive into the SNS-062 program where the first subject was dosed in 1Q16 and where preclinical data from AACR 2015 leads us to believe that this molecule could be a blockbuster in patients with acquired resistance mutations to BTK inhibitors like ibrutinib. We stay bullish. . .we believe that by 2020E, there will be ~150-200K patients treated by ibrutinib. Assuming a 10% to 15% resistance-mutation rate, there should be ~17K to 28K such patients by 2020E, potentially a multibillion market opportunity for SNS-062. We are very intrigued."

Maxim Jacobs, Edison Investment Research (4/21/16)
"Significant potential remains in Europe where Sunesis Pharmaceuticals Inc.'s Qinprezo has data comparable to those used in other related approvals. The company is also advancing SNS-062, a novel non-covalent, oral BTK inhibitor that may work in Imbruvica relapsed and refractory patients."

Hartaj Singh, BTIG Research (4/18/16)
"Near-term focus remains on European Union (EU) feedback on Sunesis Pharmaceuticals Inc.'s (Buy, $2.50 price target) vosaroxin application; other catalysts are progression of a U.S. filing strategy for vosaroxin and more color on the BTK inhibitor SNS-062 and the EU dose ranging trials. We stay bullish."

"Sunesis Pharmaceuticals Inc.'s Phase 3 VALOR trial of vosaroxin (Qinprezo) with cytarabine in patients with first relapsed or refractory acute myeloid leukemia (AML) did not achieve the primary endpoint of overall survival. But the company looked at the data, and found that there was actually a significant survival benefit in patients who were 60 years of age or older, and especially in patients who achieved a complete response. Notably, Sunesis found that the addition of vosaroxin to cytarabine more than doubled the complete response rate. So Sunesis is going after registration in the European Union (EU). This is not unlike what Eisai Inc. did with its epigenetic inhibitor Dacogen (decitabine). . .we will watch and see what happens. Meanwhile, Sunesis has an early-stage pipeline to work on, but those drugs are several years out." read more >

Hartaj Singh, BTIG Research (3/14/16)
"Sunesis Pharmaceuticals Inc. has enough cash runway until Q1/17. . .it gives the company enough breathing room to determine a suitable ex-U.S. partner for vosaroxin. . .we continue to believe in the strength of the vosaroxin data and Sunesis management's ability to gain approval in the European Union (and eventually in the U.S.), while gaining greater visibility on the pipeline."

Mara Goldstein, Cantor Fitzgerald (3/10/16)
"Sunesis Pharmaceuticals Inc. is advancing two proprietary early-stage assets (BTK and PDK1 programs) and a third compound is in early trials with partner Takeda, all of which, in our view, represent upside. Given the current valuation at less than two times cash and the possibility for upside greater than downside should either Qinprezo or the earlier-stage programs, or a combination of these possibilities, occur, we believe that a Speculative Buy rating is appropriate as the resultant share price could appreciate to the $1–4 range."

More Expert Comments

Experts Following This Company

Matthew Andrews, Equity Senior Analyst – Wells Fargo Securities
Mara Goldstein, Senior Analyst – Cantor Fitzgerald
Maxim Jacobs – Edison Investment Research
Alan Leong, CEO – BioWatch News
David Nierengarten, Research Analyst – Wedbush
Joseph Pantginis, Senior Analyst – ROTH Capital Partners
Hartaj Singh, Biotechnology Analyst – BTIG Research
George Zavoico, Senior Equity Analyst – JonesTrading

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Investing Highlights
Totality of VALOR data shows compelling risk-benefit trade-off in disease with significant unmet need
Relapsed/refractory AML is a significant commercial opportunity with no approved agents
Company's kinase inhibitor pipeline is poised to progress to the clinic in 2015 and 2016