Resverlogix Corp.

Resverlogix Corp. is developing RVX-208, a first-in-class, small molecule selective BET bromodomain inhibitor for the potential treatment of patients with cardiovascular disease, diabetes mellitus, Alzheimer's disease, peripheral artery disease and chronic kidney disease. RVX-208 is the only selective BET bromodomain inhibitor in clinical trials. The company's common shares trade on the Toronto Stock Exchange (TSX: RVX). For further information please visit www.resverlogix.com. Resverlogix can be followed on its blog at http://www.resverlogix.com/blog and via Twitter https://twitter.com/resverlogix_rvx @Resverlogix_RVX

Expert Comments:

With its lead drug candidate apabetalone already in Phase 3 targeting major adverse cardiac events, Resverlogix has expanded its scope by initiating a Phase 1 study of the small molecule to further investigate its potential applications.
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John Vandermosten, Zacks Equity Research (7/29/16)
"Resverlogix Corp.'s lead product candidate, apabetalone, is the first selective BET bromodomain inhibitor in clinical trials for high-risk vascular disease. In the current Phase 3 BETonMACE trial, Apabetalone is targeting a very specific patient population with low HDL, type diabetes mellitus and chronic kidney disease with a high cardiovascular risk for increased MACE. . .Resverlogix is based on a large and growing underserved market in cardiovascular disease. With a growing older population in the world. . .the addressable market for therapies that reduce cardiovascular risk is increasing. . .we believe the company is undervalued."

John Vandermosten, Zacks Small-Cap Research (6/29/16)
"Resverlogix Corp. began recruiting and dosing participants in the Phase 3 BETonMACE trial of its lead candidate apabetalone (RVX-208) in high-risk CVD patients with diabetes in November 2015. . .with a potential impact on multiple markers for CVD we are optimistic on a materially significant impact on MACE. . .we view Resverlogix shares as undervalued, and in a position to provide long-term upside potential. We initiate RVX at CAD$5.00 per share and believe that expansion into new geographies, the orphan disease program, and renal disease, could provide further upside to our valuation."

Marcel Wijma, Van Leeuwenhoeck Research (5/11/16)
"We believe Resverlogix is substantially undervalued. . .we have increased our valuation to CAD8.50 from CAD5.85 per share. This represents a substantial upside from the current share price. . .the increase in valuation is based on the successful licensing deal with Shenzhen Hepalink Pharmaceutical Co., the initiation of the Phase III clinical trial BETonMACE as well as the commencement of other clinical research programs with apabetalone, specifically in orphan diseases. . .with a successful Phase III trial and considering the market potential for RVX-208, we feel that a very significant upside potential for RVX-208 and Resverlogix is attainable."

"Resverlogix Corp. is an interesting resurrection story. Its lead drug, RVX-208 (apabetalone), failed in a Phase 2b clinical trial back in 2013, but then the company discovered a couple of very interesting things about the compound. Now it better understands the mechanism of action of RVX-208, which is an epigenetic inhibitor. The drug is an inhibitor of BET (bromodomain and extraterminal) domains and it was shown to increase levels of apolipoprotein A1 (ApoA1), which is a component of high-density lipoproteins (HDL/good cholesterol). This is a classic example of how a company can design a new trial from what was learned in a failed trial. Instead of giving up after the failed 324-patient Phase 2b ASSURE trial in 2013, Resverlogix made adjustments to increase its chances of success. It started a big Phase 3 trial this past October in high-risk, type 2 diabetes patients with coronary artery disease. The primary endpoint is time to first occurrence of a major cardiovascular event (MACE), with expectations that RVX-208 will also increase HDL-C, ApoA1, and large HDLs and HDL particle size. Fittingly, this Phase 3 trial is called BETonMACE. Now, after seeing the complete data set from ASSURE and other studies of RVX-208, a lot of key opinion leaders are behind the drug candidate. What's interesting about Resverlogix is that it has a whole platform behind this BET domain inhibitor story. Given its history, the issue for the company now is how to regain the confidence of Wall Street, which has memory of the failed ASSURE trial. The most likely way is with positive clinical trial data. . .Resverlogix has some independent Data and Safety Monitoring Board (DSMB) looks scheduled. . .the company is in a lower market-cap slot right now, and obviously, if and when it gets up above $250M or $500M, more institutions will jump in." read more >

"Resverlogix Corp. is focused on cardiovascular diseases, and its lead product, an epigenetic inhibitor called RVX-208 (apabetalone), aims to increase levels of apolipoprotein A1 (ApoA1) by inhibiting bromodomain and extraterminal domain (BET) protein. ApoA1 is a component of high-density lipoprotein (HDL), the good cholesterol, and its levels are raised with this drug. The company recently started a Phase 3 trial in type 2 diabetes patients at high risk for cardiovascular disease. . .you see that very big companies like Pfizer and AstraZeneca Plc dominate the space with multibillion-dollar drugs. . .this is an area where Resverlogix could make a difference. . .Resverlogix's strategy is to make a few regional partnerships. It has already partnered with Shenzhen Hepalink Pharmaceutical for a license on RVX-208 in China, Hong Kong, Taiwan and Macau. The agreement gave Resverlogix cash to start the Phase 3 trial. I think Resverlogix's strategy is to start with the clinical trial, derive data, and create value to increase the likelihood of a partnership deal with a large pharmaceutical company. I would also mention that the company has quite a lot of data from previous trials that it can use. . ." read more >

"Resverlogix Corp. is finally moving into a pivotal clinical trial with its epigenetic inhibitor RVX-208 (apabetalone), developed to increase levels of apolipoprotein A1 (ApoA1), a component of high-density lipoprotein (HDL), the "good" cholesterol. . .this trial will contain more than 2,400 high-risk cardiovascular patients with coronary artery disease and type 2 diabetes. The primary endpoint will be time to first occurrence of a major adverse cardiovascular event (MACE), which could be a non-fatal myocardial infarction, stroke or death. RVX-208 inhibits the bromodomain extraterminal domain (BET), and so they are calling the trial BETonMACE. . .Resverlogix had some interesting results with RVX-208 in its smaller proof-of-concept trials. In a couple of its more recent studies, it has gotten equivocal results. The company needs this defining trial. Results should be available in Q2/18, which sounds like a long time, but it's not when you're talking about a cardiovascular outcomes trial. . .Resverlogix has had a powerful run-up, but keep in mind that its U.S. dollar valuation is still only ~$162M. If RVX-208 is successful, there is a lot of upside left. . .you have to give kudos to the management team for committing to a large clinical outcomes trial." read more >

More Expert Comments

Experts Following This Company

Alan Leong, CEO – BioWatch News
John Vandermosten, CFA – Zacks Small-Cap Research
Marcel Wijma, Analyst – The Daily Molecule (Van Leeuwenhoeck Research), Van Leeuwenhoeck Research
George Zavoico, Senior Equity Analyst – JonesTrading

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Investing Highlights
Phase 3 Status from European Regulatory Authority for BETonMACE Clinical Trial
Combination Licensing and Equity Arrangement with China-Based Shenzhen Hepalink Pharmaceutical Co., Ltd.
Two Patents for RVX-208 in China