RXi Pharmaceuticals Corp.

RXi Pharmaceuticals Corp. is a biotechnology company focused on discovering, developing and commercializing innovative therapies based on its proprietary, next-generation RNAi platform. Therapeutics that use RNA interference, or "RNAi," have great promise because of their ability to "silence," or down-regulate, the expression of a specific gene that may be overexpressed in a disease condition. RXi's first RNAi product candidate, RXI-109, is currently in clinical trials. It targets connective tissue growth factor, a key regulatory of fibrosis and scar formation, and is initially being developed to reduce or inhibit scar formation in the skin following surgery.

Expert Comments:

Reni Benjamin, H.C. Wainwright & Co. (12/22/14)
"We are reiterating our Buy rating of RXi Pharmaceuticals Corp. . .the company announced a global licensing agreement with Hapten Pharmaceuticals LLC for rights to Samcyprone, a standardized formulation of the topical immunosensitizer, diphenylcyclopropenone. In our opinion, the agreement diversifies RXi's pipeline with a non-RNA interference product that has demonstrated efficacy in several investigator-sponsored trials for the treatment of viral warts, patchy hair loss (alopecia areata) and cutaneous metastases."

Reni Benjamin, H.C. Wainwright & Co. (11/18/14)
"We are reiterating our Buy rating of RXi Pharmaceuticals Corp. and a target price of $9. . .with a strong proprietary RNAi platform focused on dermal and ophthalmologic applications, a derisked lead asset with the potential to enter multiple therapeutic areas and a cash position of $10.1M, we believe the company represents an undervalued player with significant upside for the long-term investor."

Edward White, Laidlaw & Company (10/8/14)
"The Phase 2a photos of hypertrophic scar patients treated with RXi Pharmaceuticals Corp.'s RXI-109 following scar revision surgery presented yesterday showed significant improvement compared to placebo at three months, in our opinion. . .we are maintaining our Buy rating and price target. Our price target for the company is $8."

"RXi Pharmaceuticals Corp. has done extensive clinical trials and/or extensive research both at preclinical and clinical levels with its lead molecule, which targets a growth factor called connective tissue growth factor that plays a central role in the formation of scars. . .the company is developing products that are relatively easy to administer to the specific areas that need to be treated. By that I mean dermatological indications, which are very easily accessible, and also the eye, for ophthalmic diseases. That's RXi's way of mitigating some of the risk from the delivery point of view. Its molecules also are designed specifically to facilitate the uptake of their therapeutic payload, so that's not an issue that has to be considered separately. . .the [Phase 2] trial was designed to optimize the treatment regimen, and the one-month data did just that—the first interim analysis showed that a delayed administration of RXI-109 yielded better results than injection near the time of the surgery. . . read more >

Reni Benjamin, H.C. Wainwright & Co. (9/11/14)
"Yesterday, RXi Pharmaceuticals Corp.'s preliminary, one-month data from the first trial, focusing on lower abdominal hypertrophic scar revision, included statistically significant (p<0.001) improvement in one of two patient cohorts relative to a placebo control. . .because the study protocol includes an adaptive design, we believe these early clinical observations are critical for provide a clear path forward to optimize treatment schedules in additional cohorts, thereby boosting the chances of success for the entire program."

Edward White, Laidlaw & Company (9/11/14)
"Yesterday, RXi Pharmaceuticals Corp. announced one-month interim data from two cohorts of its Phase 2a RXI-109-1301 study in patients with lower abdominal hypertrophic scars. . .given the physiology of wound healing and the significant data for the second cohort, we have increased confidence in the ultimate success of the 1301 study as the remainder of the trial will administer new patients delayed dose of the drug (first dose at t+14 days) following surgery. We view this early decision to restructure the cohorts as a strong positive."

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Investing Highlights
 
Multiple development opportunities within the Company's Dermatology and Ophthalmology franchises
 
Leader in the development of advanced RNAi-based therapeutics
 
Broad and robust intellectual property portfolio
RXi Pharmaceuticals Corp. Content