ProMIS Neurosciences Inc.

The mission of ProMIS Neurosciences is to discover and develop precision medicine therapeutics for best in class treatment of neurodegenerative diseases, in particular, Alzheimer’s disease (AD) and ALS. ProMIS Neurosciences’ proprietary target discovery engine is based on two, complementary techniques. The Company applies its thermodynamic, computational discovery platforms—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes on the surface of misfolded proteins. ProMIS has identified five target sites on toxic, misfolded strains of amyloid beta, a known root cause of Alzheimer’s, and created five antibodies specific to these targets (without targeting amyloid beta monomer or plaque, known to be related to poor efficacy and side effects). Results of prior clinical trials indicate best in class AD therapy should target specifically toxic, misfolded strains of Amyloid beta and not the other forms. ProMIS’ AD program is uniquely designed and on track to achieve this goal; lead antibody product, PMN310 is in late preclinical development, with IND submission planned for late 2018.

Expert Comments:

In its corporate update for Q2/17, a Canada-based biotech targeting neurological disorders including Alzheimer's disease informed investors of advancements in several programs, including designation of a second validated lead compound in development.
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Management Q&A: View From the Top
Elliot Goldstein
With the impacts of Alzheimer's disease on patients, doctors and the health care industry expected to burgeon over the next decade, ProMIS Neurosciences has developed a preclinical program that targets the root cause of the disease, and also offers the potential to get in on an investment with a double bottom line, says Elliot Goldstein, CEO of ProMIS, in this interview with The Life Sciences Report.
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"ProMIS Neurosciences Inc. is a preclinical company, but it will be going in the clinic over the next year or so. I'm in it because of some of the really important insights it has discovered into the mechanism of action of Alzheimer's disease. What ProMIS has discovered is that the ideal thing to target for Alzheimer's is soluble amyloid beta oligomers. It believes that they are the root cause of Alzheimer's, not the plaque that ultimately settles on the brain.

ProMIS has discovered that by focusing on IgG 4 isotype, you can circumvent the inflammation that often comes with monoclonal antibodies. ProMIS has identified six epitopes on protein strains of misfolded amyloid precursor proteins (APPs). APPs are the misfolded proteins that eventually lead to something called fibrils, which eventually clot and form plaques in the brain. ProMIS has discovered that the prion strains of those misfolded proteins carry a marker, called an epitope. It's like a police car with a light on top. ProMIS has developed five murine antibodies that select for those epitopes so antibodies can find them on those misfolded proteins and bind to them. It is actually a pretty profound breakthrough at this level. Again, it's very early stage and preclinical. But ProMIS has selected one of those five antibodies. The drug that it's going to advance, PMN-310, will be its first candidate in clinic. I bought into ProMIS on a financing in the summer of 2015. I'll probably hold it for another 5 or 10 years. It's achieved a lot with very little, and its understanding of the mechanism of action of Alzheimer's is quite significant. I think we'll hear about that over the course of 2017." read more >

Experts Following This Company

Eden Rahim, Portfolio Manager and Options Strategist – Next Edge Capital

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